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Applications of MRS in the evaluation of focal malignant brain lesions
Abstract
Magnetic resonance spectroscopy (MRS) has clinically been most
extensively used for assessing brain disorders, particularly
tumors. With 1-H spectroscopy at intermediate echo times,
resonances from choline, creatine, Nacetyl-aspartate (NAA),
lactate, and free fatty acids can be resolved well enough to
assist in diagnosis under routine conditions. Generally, an
increased concentration of choline is found in all primary and
secondary brain tumors, and the degree of increase correlates
with the degree of anaplasia. Further indicators of anaplasia
are the presence of lactate, indicating hypoxia, and of fatty
acids, indicating necrosis. According to literature, the
sensitivity of a combination of proton spectroscopy with
contrast-enhanced dynamic susceptibility-weighted imaging for
high-grade components in gliomas is better than conventional
contrast-enhanced imaging alone. Today, proton spectroscopy is
clearly indicated for differentiating radiation-induced damage
from recurrences of irradiated brain tumors.
Author
S Delorme and M-A Weber
Contact Details
Corresponding address:
Stefan Delorme, MD,
German Cancer Research Center (dkfz),
Department of Radiology (E010),
Im Neuenheimer Feld 280,
69120 Heidelberg,
Germany
Reference
ICIS Cancer Imaging Volume 6 Issue 1
DOI: 10.1102/1470-7330.2006.0015
Date Posted
22 June 2006
Open Access is provided for this article.
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