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The radiology of gastrointestinal stromal tumours (GIST)
Abstract
Gastrointestinal stromal tumours (GISTs) comprise a group of
smooth muscle mesenchymal alimentary tract tumours of variable
malignancy. Recently, the pathophysiology and radiology of these
tumours has generated enormous interest following the discovery
of a specific, highly effective, chemotherapeutic agent in the
form of ST-571 (Imatinib; Glivec, Novartis, Frimley UK). At the
time of this review, 106 patients with malignant
gastrointestinal stromal tumours seen at the Royal Marsden
Hospital have been entered into trials examining the efficacy of
varying doses of Imatinib. Burkill et al., also from the Royal
Marsden Hospital, have previously reported the distribution,
imaging features and pattern of metastatic spread of these
tumours (Burkill GJ, Badran M, Al-Muderis O et al. Malignant
gastrointestinal stromal tumor: distribution, imaging features,
and pattern of metastatic spread. Radiology 2003; 226: 527--32).
This new review re-examines the radiological features of GISTs
at presentation and well as their changed imaging features
following treatment with Imatinib.
Author
D Michael King
Contact Details
Corresponding address:
D Michael King, FRCR,
Department of Diagnostic Imaging,
Royal Marsden NHS Foundation Trust,
Fulham Road, London, SW3 6JJ, UK
Reference
ICIS Cancer Imaging Volume 5
DOI: 10.1102/1470-7330.2005.0109
Date Posted
15 December 2005
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